Daptomycin treatment in patients with resistant staphylococcal periprosthetic joint infection

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Daptomycin treatment in patients with resistant staphylococcal periprosthetic joint infection 

BACKGROUND Resistant staphylococcal organisms remain a serious problem in the treatment of periprosthetic joint infection (PJI). Higher failure rates have been reported when vancomycin was used. The purpose of this study was to assess the clinical dosage, effect, and safety of daptomycin in patients with resistant staphylococcal PJI. METHODS We retrospectively enrolled patients with hip or kn...

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Methicillin-resistant Staphylococcal periprosthetic joint infections can be effectively controlled by systemic and local daptomycin

BACKGROUND Methicillin-resistant Staphylococcus remains a serious problem in the treatment of periprosthetic joint infection (PJI). Higher failure rates were reported when vancomycin was used in 2-stage exchange arthroplasty. Therefore a better therapeutic drug is needed to treat PJI caused by methicillin-resistant organisms. The purpose of the study was to evaluate the safety and efficacy of d...

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Prevention of Periprosthetic Joint Infection

Prosthetic joint infection (PJI) is a calamitous complication with high morbidity and substantial cost. The reported incidence is low but it is probably underestimated due to the difficulty in diagnosis. PJI has challenged the orthopaedic community for several years and despite all the advances in this field, it is still a real concern with immense impact on patients, and the healthcare system....

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Clinical experience with daptomycin for the treatment of patients with knee and hip periprosthetic joint infections.

OBJECTIVES To investigate the clinical efficacy and safety of daptomycin in the treatment of hip and knee periprosthetic joint infections (PJIs). METHODS We completed a retrospective review of all patients in our institution (n=20) who were treated with daptomycin for hip or knee PJI, over the 36 month period from January 2008 until December 2010. RESULTS Infection types included eight case...

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ژورنال

عنوان ژورنال: BMC Infectious Diseases

سال: 2017

ISSN: 1471-2334

DOI: 10.1186/s12879-017-2842-6